Pair Name	Jervine, Decitabine
Disease Info	[ICD-11: 2A3Z]	Myelodysplastic syndrome		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	AKT1	hsa207
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	Gli1	hsa2735
	Down-regulation	Expression	PIK3CA	hsa5290
	Down-regulation	Expression	SMO	hsa6608
In Vitro Model	MUTZ-1	EBV-related Burkitt lymphoma	Homo sapiens (Human)	CVCL_1431
Result	The Smo inhibitor jervine and its combination with decitabine have a synergistic effect on the proliferation, cell cycle, and apoptosis of MUTZ-1 cells, and its mechanism may be achieved by interfering with the Shh signaling pathway.